2025 01 v.40 24-34
金属有机框架（MOFs）材料在天然产物研究中的应用
基金项目(Foundation):
安徽高校自然科学研究项目（KJ2020A0666）;
合肥大学研究生创新研究项目（2024Yxscx25）
邮箱(Email):
xutao@hfuu.edu.cn;
DOI:
中文作者单位:
合肥大学生物食品与环境学院;
摘要(Abstract):
天然产物是由动物、植物、微生物等产生的化学成分的统称，具有广泛的生理活性如抗菌、抗病毒、抗肿瘤、抗氧化和免疫调节活性等，是药物发现和创新的重要来源.然而，从复杂的自然环境中高效提取、分离并纯化这些具有生理活性的天然产物，一直是科学家们面临的挑战.随着材料科学的飞速发展，金属有机框架（MOFs）材料以其独特的结构和性质，为解决这一难题提供了新的思路. MOFs材料的高比表面积、高孔隙度以及孔径可调等特点，使其能够作为高效的吸附剂和分离介质，在天然产物的提取和分离过程中展现出巨大的潜力.同时，MOFs材料的化学和热稳定性也为其在天然产物后续处理、合成及色谱分析中的应用奠定了坚实的基础.因此，探索MOFs材料在天然产物领域的应用，不仅有助于提升天然产物的提取效率与纯度，还可以为新药开发、生命科学研究开辟新的途径.本文对近年来MOFs材料在天然产物分离与分析、天然产物合成、药物制剂等领域的应用进行了分析和总结，同时也对未来MOFs材料在天然产物领域的应用进行了展望.
关键词(KeyWords):
金属有机框架材料;MOFs;天然产物;分离纯化
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[28]杜峰，李鹂. UiO-66(Zr)系列MOFs催化材料的制备及在乳酸乙酯合成中的应用[J].化工进展，2015,34(11):3938-3943+3950.
[29] KIM S,PARK C G,HUH B K,et al. Metal-organic frameworks,NH2-MIL-88(Fe),as carriers for ophthalmic delivery of brimonidine[J]. Acta Biomaterialia,2018,79:344-353.
[30]王洁莹.金属有机骨架材料的合成及其负载5-氟尿嘧啶的性质研究[D].沈阳：沈阳师范大学，2017:1-58.
[31] PENG L,YANG X,WANG S,et al. Bimetal metal-organic framework domino micro-reactor for synergistic antibacterial starvation/chemodynamic therapy and robust wound healing[J]. Nanoscale,2022,14(5):52-64.
[32] SHAO Y,SUO H,WANG S,et al. A facile method to construct ZIF-8 MOFs on contact lens for high antibiotics loading and self-defensive release[J]. Chemical Engineering Journal, 2024, 481:148576.
[33] GUO Y F,FANG W J, FU J R, et al. Facile synthesis of Ag@ZIF-8 core-shell heterostructure nanowires for improved antibacterial activities[J]. Applied Surface Science, 2018, 435:149-55.
[2] NEWMAN D J, CRAGG G M. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019[J]. Journal of Natural Product. 2020,83,770-803.
[3]刘永峰，郝丽云，魏鉴腾，等.共价有机骨架材料在天然产物中的应用[J].鲁东大学学报（自然科学版），2023,39(4):311-321.
[4]郑修飙.新型金属有机框架复合材料的制备及其在电化学传感器中的应用[D].常州：常州大学，2021:1-60.
[5]谢慧荣，罗忠圣，钱余，等.膜分离技术在天然产物中的应用[J].食品科技，2021, 46(5):104-107.
[6] LAU E C, MASON D J, EICHHORST N, et al. Functional chromatographic technique for natural product isolation[J]. Organic&Biomolecular Chemistry,2015,13(8):2255-2259.
[7]杨光，波拉提·马卡比力.浅析固相萃取法在天然产物研究中的应用[J].世界临床药物，2006,(12):765-767.
[8]郭文娟，朱大伟，代昭，等. MOFs材料对普洱茶中总黄酮的吸附[J].天津工业大学学报，2019,38(2):38-44.
[9] LU M Y,XIE Y B,HUANG H L,et al. Purification of borneol from its isomeric mixture by using metal-organic frameworks[J]. Separation and Purification Technology,2023,304:122213.
[10]任和，张瑞平，郭文娟，等. MOF材料用于肉苁蓉总黄酮的富集研究[J].应用化工，2024,53(10):2308-2314.
[11] LU M Y,BAI X,YU J,et al. Separation of borneol/camphor natural products mixture with MIL-101(Cr)[J]. Journal of the Taiwan Institute of Chemical Engineers,2024,156:105390.
[12] ZHANG X,LIN R B,WU H,et al. Maximizing acetylene packing density for highly efficient C2H2/CO2separation through immobilization of amine sites within a prototype MOF[J].Chemical Engineering Journal,2022,431(P2):134184.
[13] CUI Y,YANG C,YANG X,et al. Zeolitic imidazolate framework-8 for selective extraction of a highly active anti-oxidant flavonoid from Caragana Jubata[J]. Journal of Chromatography A,2018,1544:8-15.
[14]刘亚，王雨，陈莹莹，等. MOF-5吸附姜黄素及在胃肠中的消化研究[J].食品科学技术学报，2017,35(5):46-52.
[15]冯军军，王静，赵连兴，等.基于UiO-66-NH2金属有机框架材料的固相萃取/高效液相色谱-串联质谱法测定饮料和配制酒中的新红[J].分析测试学报，2023,42(3):299-306.
[16] MA M C,LU X F,WANG L C,et al. A stable core-shell metal-organic framework@covalent organic framework composite as solid-phase extraction adsorbent for selective enrichment and determination of flavonoids[J]. Journal of Chromatography A,2023,1707:464324.
[17]许国强. Fe系MOFs@MIPs复合印迹材料的合成及其吸附研究[D].吉首市：吉首大学，2023.
[18] WANG Y,YIN S,ZHAO C,et al. Preparation of a zirconium terephthalate metal organic framework coated magnetic nanoparticle for the extraction of berberine prior to high performance liquid chromatography analysis[J]. Journal of Separation Science,2021,44(6):1220-1230.
[19] Nuzhdin A L,Dybtsev D N,Bryliakov K P,et al. Enantioselective chromatographic resolution and one-pot synthesis of enantiomerically pure sulfoxides over a homochiral Zn-organic framework[J]. Journal of the American Chemical Society,2007,129(43):12902-13358.
[20] YANG C X,CHEN Y J,WANG H F,et al. High performance separation of fullerenes on metalorganic framework MIL-101(Cr)[J]. Chemistry-A European Journal,2011,17(42):11734-11737.
[21] LIU S S,YANG C X,WANG S W,et al. Metal-organic frameworks for reverse-phase high-performance liquid chromatography[J]. The Analyst,2012,137:816-818.
[22] DAI Q,MA J Q,MA S Q,et al. Cationic ionic liquids organic ligands based metal-organic frameworks for fabrication of core-shell microspheres for hydrophilic interaction liquid chromatograp hy[J]. ACS Applied Materials&Interfaces,2016,8(33):21632-21639.
[23] Li X Y,Li B,Liu M C,et al. Core-shell metal-organic frameworks as the mixed-mode stationary phase for hydrophilic interaction/reversed-phase chromatography[J]. ACS Applied Materials&Interfaces,2019,11(10):10320-10327.
[24]刘家玮，刘湘唯，Habib Ur Rehman，等.金属有机框架色谱固定相的研究进展[J].分析测试技术与仪器，2021,27(2):65-76.
[25] Meng S S, Xu M, Han T, et al. Re gulating metal-organic frameworks as stationary phases and absorbents for analytical separations[J]. Analytical Methods,2021,13(11):1318-1331.
[26] CHEN K, ZHANG L, ZHANG W. Preparation and evaluation of open-tubular capillary column combining a metal-organic framework and a brush-shaped polymer for liquid chromatography[J]. Journal of Separation Science, 2018, 41:2347-2353.
[27]汤雯淇，孟莎莎，徐铭，等.基于金属有机骨架材料固定相的气相色谱分离应用[J].色谱，2021,39(1):57-68.
[28]杜峰，李鹂. UiO-66(Zr)系列MOFs催化材料的制备及在乳酸乙酯合成中的应用[J].化工进展，2015,34(11):3938-3943+3950.
[29] KIM S,PARK C G,HUH B K,et al. Metal-organic frameworks,NH2-MIL-88(Fe),as carriers for ophthalmic delivery of brimonidine[J]. Acta Biomaterialia,2018,79:344-353.
[30]王洁莹.金属有机骨架材料的合成及其负载5-氟尿嘧啶的性质研究[D].沈阳：沈阳师范大学，2017:1-58.
[31] PENG L,YANG X,WANG S,et al. Bimetal metal-organic framework domino micro-reactor for synergistic antibacterial starvation/chemodynamic therapy and robust wound healing[J]. Nanoscale,2022,14(5):52-64.
[32] SHAO Y,SUO H,WANG S,et al. A facile method to construct ZIF-8 MOFs on contact lens for high antibiotics loading and self-defensive release[J]. Chemical Engineering Journal, 2024, 481:148576.
[33] GUO Y F,FANG W J, FU J R, et al. Facile synthesis of Ag@ZIF-8 core-shell heterostructure nanowires for improved antibacterial activities[J]. Applied Surface Science, 2018, 435:149-55.
基本信息:
DOI：
中图分类号:O641.4;O629
引用信息:
[1]徐涛,曾志豪,张婷婷等.金属有机框架（MOFs）材料在天然产物研究中的应用[J].汕头大学学报(自然科学版),2025,40(01):24-34.
基金信息:
安徽高校自然科学研究项目（KJ2020A0666）; 合肥大学研究生创新研究项目（2024Yxscx25）