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天然产物是由动物、植物、微生物等产生的化学成分的统称，具有广泛的生理活性如抗菌、抗病毒、抗肿瘤、抗氧化和免疫调节活性等，是药物发现和创新的重要来源.然而，从复杂的自然环境中高效提取、分离并纯化这些具有生理活性的天然产物，一直是科学家们面临的挑战.随着材料科学的飞速发展，金属有机框架（MOFs）材料以其独特的结构和性质，为解决这一难题提供了新的思路. MOFs材料的高比表面积、高孔隙度以及孔径可调等特点，使其能够作为高效的吸附剂和分离介质，在天然产物的提取和分离过程中展现出巨大的潜力.同时，MOFs材料的化学和热稳定性也为其在天然产物后续处理、合成及色谱分析中的应用奠定了坚实的基础.因此，探索MOFs材料在天然产物领域的应用，不仅有助于提升天然产物的提取效率与纯度，还可以为新药开发、生命科学研究开辟新的途径.本文对近年来MOFs材料在天然产物分离与分析、天然产物合成、药物制剂等领域的应用进行了分析和总结，同时也对未来MOFs材料在天然产物领域的应用进行了展望.
Abstract：Natural products are collectively referred to as the chemical components produced by animals, plants, microorganisms, etc., with a wide range of physiological activities such as antibacterial, antiviral, antitumor, antioxidant, and immunomodulatory activities. They serve as an important source for drug discovery and innovation. Nevertheless, the efficient extraction,separation, and purification of these natural products with physiological activities from the complex natural environment have consistently been a challenge for scientists. With the rapid development of materials science, metal-organic frameworks(MOFs)materials with distinctive structures and properties have offered new ideas for addressing this difficulty. The characteristics of MOFs materials, such as high specific surface area, high porosity, and adjustable pore size,enable them to function as highly efficient adsorbents and separation media, demonstrating substantial potential in the extraction and separation processes of natural products. Simultaneously,the chemical and thermal stability of MOFs materials also lays a solid foundation for their application in the subsequent processing, synthesis, and chromatographic analysis of natural products. Therefore, exploring the application of MOFs materials in the domain of natural products not only contributes to enhancing the extraction efficiency and purity of natural products, but also has the potential to pioneer new paths for new drug discovery and life science research. In this paper, the application of MOFs materials in the separationand analysis of natural products, synthesisof natural products and pharmaceutical preparation are discussed andsummarized. It also provides an outlook on the future application of MOFs materials in the field of natural products.
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基本信息:
DOI：
中图分类号:O641.4;O629
引用信息:
[1]徐涛,曾志豪,张婷婷等.金属有机框架（MOFs）材料在天然产物研究中的应用[J].汕头大学学报(自然科学版),2025,40(01):24-34.
基金信息:
安徽高校自然科学研究项目（KJ2020A0666）; 合肥大学研究生创新研究项目（2024Yxscx25）